Zytaze - make Botulinum Toxin injections last 30% longer

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ZYTAZE® is a medical food that provides nutritional support to enhance the effectiveness of botulinum toxin injections in the treatment of blepharospasm, hemifacial spasm or cosmetic procedures.

Formulated with a unique blend of organic zinc and phytase to increase zinc absorption, ZYTAZE® has been found to extend the duration of botulinum toxin injections by 30%*.


What is botulinum toxin?

Botulinum toxin is a protein derived from Clostridium botulinum that helps stop muscle spasms. Muscle spasms are caused by chemical messages sent to the muscles from nerves. These messages tell the muscles to contract (tighten up). Botulinum toxin blocks these messages.

What is a blepharospam?

A blepharospasm, blepharo meaning eyelid and spasm meaning uncontrolled muscle contraction, is any abnormal, involuntary contraction or twitch of the eyelid. It normally refers to benign essential blepharospasm (BEB) which is a focal dystonia — a neurological movement disorder involving involuntary and sustained contractions of the muscles around the eyes. Symptoms sometimes last for a few days then disappear without treatment, but in most cases the twitching is chronic and persistent, causing lifelong challenges.

What is a hemifacial spasm?

A hemifacial spasm, hemi meaning one side, facial meaning face and spasm meaning uncontrolled muscle contraction, is a neuromuscular disorder characterized by frequent involuntary contractions of the muscles on one side of the face.

What are the ingredients in ZYTAZE®?

Each capsule contains Zinc as Zinc Citrate 25 mg and Phytase 1500 mg. Other ingredients include: Silicon Dioxide, Magnesium Stearate, and Microcrystalline Cellulose.

What is phytase?

Phytase is an enzyme that effectively breaks down phytates, a group of phosphate-containing compounds which tightly bind zinc in the intestinal tract and prevent zinc absorption. Phytates are found in whole grain breads, whole-wheat products, many cereals, soy, oats, legumes (including peas, peanuts and peanut butter), beans, co, nuts, rice, and other foods as well.

Why should I take ZYTAZE® before my next injection(s)?

To be effective, each molecule of botulinum toxin must be associated with a molecule of zinc. Unfortunately, not all zinc is the same and taking a poorly absorbed form of zinc can compete with absorption with better zinc available through foods, which can be worse than taking no zinc at all. ZYTAZE® is specially formulated with a unique patent-pending combination of organic zinc and phytase to maximize zinc absorption, thereby enhancing the effectiveness of botulinum toxin injections.

If I take more zinc and phytase, will it increase the effectiveness of my botulinum toxin injections?

More of a good thing is not necessarily better. Too much zinc can cause gastrointestinal symptoms of nausea, vomiting, diarrhea, and stomach pain as well as dizziness, kidney ysfunction, anemia, and decreased immune function. Too much zinc may actually DECREASE the effect of botulinum toxins. Too much phytase on a regular basis may cause too much zinc absorption resulting in the previously mentioned side effects. Consuming a controlled amount of zinc and phytase prior to and at the time of receiving botulinum toxin injections is recommended to enhance effects without the risk of zinc toxicity.

What is the recommended dosage of ZYTAZE®?

Two capsules daily for four days prior to and on the day of receiving botulinum toxin injections. Each prescription package contains 10 capsules. ZYTAZE® may be taken during meals or snacks, but avoid taking ZYTAZE® within two hours of medications and/or supplements. ZYTAZE® is a medical food and is intended to be used under the supervision of a physician.

How is ZYTAZE® supplied?

ZYTAZE® is supplied in a blister pack of 10 clear, hard-shell capsules containing a white/off white crystalline powder.

Will ZYTAZE® enhance the effects of dermal fillers?

No. The ingredients in ZYTAZE® are specifically formulated to support the effectiveness of botulinum toxins. For best results, use ZYTAZE® in conjunction with botulinum toxin treatments.

Are there any known side effects to taking ZYTAZE®?

There are no known side effects of zinc at normal dosages or of phytase used for short durations. Zinc at dosages above 50 mg daily is associated with reduced immune system unctioning and is therefore not recommended.

What are the contraindications for ZYTAZE®?

ZYTAZE® should not be used without physician supervision, or in those persons showing hypersensitivity to any component of this preparation. Zinc may decrease the absorption of tetracycline and ciprofloxacin. Take any zinc supplement at least two hours before or after taking these antibiotics. Use of the following drugs increases the loss of zinc from the body or interferes with absorption: aspirin; azidothymidine, zidovudine; captopril; enalapril; estrogen oral contraceptives; penicillamine; the thiazide class of diuretics including chlorothiazide, chlorthalidone, hydrochlorothiazide, metolazone. No known contraindications for phytase. Women who are pregnant, nursing or may become pregnant should consult their physician before using this product. Zinc supplements may cause mild nausea in susceptible persons when taken on an empty stomach. Avoid taking within two hours of medications and/or supplements.

* ¹Koshy JC, Sharabi SE, Feldman EM, Hollier LH, Patrinely JR, Soparkar CNS. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol 2012 Apr 1; 11(4):507-12